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Rohan Paul· @rohanpaul_ai · X·· 3 小时前AI 评分64
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Rohan Paul 转述 Anthropic 科学博客:Claude 以智能体形式在 Anthropic 的 Claude Science 环境中自主完成蛋白质设计,从 318,484 个生成分子中选出 180 个用于合成,211 个测试设计中 17 个在 Adaptyv Bio 和 Twist Bioscience 验证可结合蝎神经毒素。

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Claude did the protein scientist’s job and came back with 17 molecules that grip scorpion neurotoxins.

Claude, running as an agent inside Anthropic’s Claude Science setup, ran the whole protein-design campaign itself:

it picked which patch of each scorpion toxin to attack, drove 12 protein-design programs, set its own scoring cutoffs, and chose 180 molecules out of the 318,484 it generated for physical synthesis, and 17 of the 211 designs tested bound their toxin at Adaptyv Bio and Twist Bioscience.

Citrini Research, a finance firm with no lab and no protein expertise, asked for this work, and Claude designed proteins that two labs confirmed latch onto scorpion venom toxins.

Scorpion stings kill more than 3,250 people a year, so the prize is real, if this method works. However, Anthropic is not calling this an antivenom, because the test that would justify the word has not been run yet.

引用Anthropic@AnthropicAI
New on our Science Blog: designing protein binders against scorpion neurotoxins. Scorpions sting about 1.2m people every year, and antivenoms are often costly or in short supply. Claude has made an early step toward finding new treatments. https://www.anthropic.com/research/claude-scorpion-toxin-binder-design
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来源:Rohan Paul · x.com